Dr. Francis Collins has had a distinguished career by any measure. A leading figure in the mapping of the human genome sequence, he’s worked to translate that discovery into a revolution in medical treatment. In 11 years as director of the National Institutes of Health, he’s overseen a nearly 40% growth in the agency’s budget. He’ll be stepping down as director at the end of the year, but continuing to lead the laboratory at the National Human Genome Research Institute. Federal Drive with Tom Temin spoke with him about some of the big questions.