Freshmen Duane Washington Jr. scored 14 points, Jaedon Ledee added 12 and Luther Muhammad had 11 for the Buckeyes.
Damani Applewhite scored 15 points and Aramani Hill had 11 for the Bulldogs (1-4).
Ohio State shot 55 percent from the floor (28 of 51) to the Bulldogs’ 37 percent (23 of 62).
South Carolina State: The Bulldogs are trying to develop a winning culture with a batch of new players. Only Damani Applewhite and Janai Raynor-Powell return from last season’s team that finished 10-22 for sixth-year coach Murray Garvin. Early indications are it will be another tough season for the Bulldogs, but playing a team the caliber of Ohio State can be of value in the long haul.
Ohio State: Chris Holtmann, the 2017-18 Big Ten coach of the year, expected the Buckeyes to take a step back with six new faces but the early results continue to be positive with road wins at Cincinnati and Creighton.
South Carolina: Plays the fifth of eight straight road games Tuesday at Purdue Fort Wayne. The Mastodons lost 107-61 at Ohio State on Nov. 11.
Ohio State: Takes on Samford on Tuesday and could have another opportunity to build confidence.