The group winner advances to the Final Four in June. Poland is already assured of finishing last in the group and will be relegated to League B.
Mancini was hired after previous coach Gian Piero Ventura was blamed for Italy’s failed World Cup qualification.
“I see a team that wants to roll its sleeves up and bring Italy back where it belongs,” Mancini said. “Let’s be clear, we still need some time, but we’re on the right path.”
Defender Giorgio Chiellini is slated to make his 100th appearance for Italy while wearing the captain’s armband.
“I want to celebrate the achievement only at the end of the match,” Chiellini said. “First let’s focus on Portugal, try to bring home three points and provide continuity to the good work done to this point.”
Chiellini retired from the national team in the aftermath of the loss to Sweden but then changed his mind.
“The real disappointment came in June when many of my club teammates left for Russia while I was preparing my suitcases for vacation,” Chiellini said.
Fellow defender Alessio Romagnoli left Italy’s squad on Friday with a muscular injury, and Italy is also without forward Federico Bernardeschi.
Bernardeschi was a key performer in the 1-0 win over Poland last month, lining up alongside Lorenzo Insigne and Federico Chiesa.
Unable to use the same lineup, Mancini announced that Ciro Immobile will likely start at center forward.
Italy has had trouble scoring.
The last time the Azzurri scored more than one goal was in May, a 2-1 win over Saudi Arabia in a friendly , while the last time they accomplished the feat in a competitive match was in June 2017, a 5-0 victory over Liechtenstein in a World Cup qualifier.
Italy next plays the United States in a friendly in Genk, Belgium, on Tuesday.
Mancini announced Chiellini, Alessandro Florenzi, Jorginho and Insigne would be sent home after the Portugal game and Gianluca Mancini and Moise Kean would be called up from the under-21 side.
Mancini and Chiellini both expressed disappointment that Ronaldo, who is taking a break from the national team, isn’t with Portugal.
“It’s always great to face the best players,” Mancini said. “Anyhow, Portugal remains a great squad even without Cristiano.”
More AP soccer: https://apnews.com/tag/apf-Soccer and https://twitter.com/AP_Sports