Gurley is the NFL’s second-leading rusher with 1,251 yards.
The Saints’ Austin Carr is the odd man out in New Orleans’ receiver group after Ted Ginn returned this week from an arthroscopic knee procedure that kept him out injured more than half the season. Left tackle Terron Armstead also makes a timely return to the lineup from his chest injury while fellow tackle Jermon Bushrod sits out with a sore hamstring.
For Pittsburgh, receiver JuJu Smith-Schuster is active after being listed as questionable because of a sore groin that limited him in practice this week.
Here’s the full list of inactives for Sunday’s games: