Jordy Mercer’s RBI double gave the Tigers a 6-3 lead, but the Mariners answered with a six-run sixth that included Seager and Murphy’s second set of back-to-back homers.
Seager’s three-run homer tied the game and Murphy followed with a long homer to left to put the Mariners up 7-6. Nick Ramirez replaced Boyd, but allowed two more runs without getting an out.
In the ninth, Seager hit a drive to deep left-centerfield that would not have been a home run, but centerfielder Niko Goodrum and leftfielder Brandon Dixon collided on the warning track. The ball hit Goodrum’s glove and bounced over the fence.
Mariners: RHP Brandon Brennan started the sixth inning for the Mariners, but left with pain in his left great toe after throwing two pitches. Sam Tuivailala replaced him and pitched a scoreless inning.
Mariners hitting coach Tim Laker was ejected in the seventh inning for arguing balls and strikes.
BOYD’S HOMER ISSUES
Boyd has allowed seven homers in his past two starts, giving him 19 in 11 starts at Comerica Park. Justin Verlander has the stadium record with 20 in 2016.
The teams play the second game of a three-game series on Wednesday evening, with Detroit’s Edwin Jackson (2-5, 9.35) making his second start since returning to the Tigers. Marco Gonzalez (12-9, 4.25) is scheduled to pitch for Seattle.