Andre Burakovsky scored twice, Joonas Donskoi had a goal and two assists, Matt Nieto also scored and Philipp Grubauer stopped 40 shots for Colorado.
Jonathan Huberdeau scored twice for Florida, Brett Connolly and Frank Vatrano added goals and Sergei Bobrovsky made 36 saves.
Connolly gave the Panthers a 4-3 lead with 5:55 left in the second, and Burakovsky tied it 16 seconds later when he banged in a rebound.
“We had a complete first period, turning in the right direction for sixty and we let off the gas there, pursuing the puck or keeping it,” Panthers coach Joel Quenneville said. “We got slow as that period progressed. We scored a big goal, then gave up one simultaneously. That can’t happen.”
Colorado scored twice in a 32-second span midway through the second period to tie it a 3.
Pierre-Edouard Bellemare passed from behind the net to Nieto and he beat Bobrovsky to make it 3-2. Burakovsky’s first goal, a shot from the top of the right circle, tied it with 8:05 left in the period.
“In previous games, we’ve been struggling in the second,” Burakovsky said. “I think we turned that around today and we were strong in the second and third.”
The Panthers took a 2-0 lead in the first on goals by Huberdeau and Vatrano.
“Loose. That’s what it was. It was loose. They (Panthers) came out firing on all cylinders,” Avalanche coach Jared Bednar said. “Early on I didn’t like it, and then the second period starts to come around.”
NOTES: The Avalanche are the only NHL team left without a regulation loss. … Vatrano scored short-handed. … Colorado defenseman Nikita Zadorov returned after being a healthy scratch Wednesday.
Avalanche: At Tampa Bay on Saturday night.
Panthers: At Nashville on Saturday night.
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