Instead, Lazio took the lead moments later when Lecce goalkeeper Gabriel slipped under pressure from Ciro Immobile. He still managed to parry the first Lazio attempt but Caicedo hit the rebound into an empty net.
Lecce leveled on the half hour mark when Babacar was left unmarked, eight yards out, to head in Filippo Falco’s cross.
The home side had a great chance to take the lead in first-half stoppage time but Mancosu blasted a penalty over the bar, following handball from Patric.
However, Lecce did go in front two minutes after the break when Lucioni headed in a corner.
Gabriel atoned for his early error with several saves to keep Lecce in front, including stopping Bobby Adekanye’s header from point-blank range, four minutes from time.
Lazio’s bad night was complete when Patric was sent off for biting Giulio Donati.