UConn also dominated underneath, outscoring DePaul 38-12 in the paint. Nelson-Ododa hit seven of her 11 shots in her third double-double of the season and 12th of her career.
Christyn Williams scored the 1,000th point of her UConn career on a layup that gave UConn an early 4-0 lead, but the Huskies led just 20-16 after a quarter. Williams finished with 14 points, eight rebounds and five assists.
A 3-pointer by Bueckers from the left corner gave the Huskies their first double-digit lead at 28-17 and UConn took a 38-27 advantage into intermission.
DePaul: The Blue Demons fell to 1-3 this season against ranked opponents, with losses to Texas A&M (93-91) and Louisville (116-75) and a win over Kentucky (86-82). The Blue Demons have never beaten the Huskies during coach Geno Auriemma’s tenure, losing all 18 of those games. Their only win against UConn came 37 years ago, on Dec. 28, 1983.
UConn: The Huskies came into the game holding opponents to 23% shooting. They have not allowed an opponent to shoot better than 35% or score more than 65 points.
DePaul: The Blue Demons head to Milwaukee to face Marquette on Sunday.