Phillies starter Aaron Nola (3-4) gave up five runs — four earned — and seven hits, striking out nine in five innings.
Nola fanned the first two batters in the fifth before running into trouble. Santana blasted a 1-2 pitch out to right to give Boston a 3-2 lead. After Alex Verdugo singled and J.D. Martinez walked, Xander Bogaerts lined a single to left. Third baseman Alec Bohm cut off left fielder Andrew McCutchen’s throw to the plate, even though it appeared there would be a play at home. Bohm’s throw to second base sailed into the outfield, allowing Martinez to score for a 5-2 lead.
Hunter Renfroe’s RBI single off Connor Brogdon in the sixth expanded Boston’s lead to 6-2.
Devers hit a two-run shot off Brogdon in the seventh for his 12th homer of the season.
Philadelphia’s Jean Segura crushed a two-run homer out to left-center, tying it at 2-2 in the third.
Boston jumped ahead 2-0 in the first on a RBI groundout by Bogaerts and RBI double by Devers.
Nola pitched at least seven innings and allowed two runs or fewer on four hits or fewer in his first three starts against the Red Sox before this one.
In his first game with the Red Sox and first since having right elbow surgery last September, Santana batted leadoff and played first base. Manager Alex Cora said he plans to use Santana at first, second and center field.
The Phillies made three errors, two for Bohm and one for McCutchen.
Red Sox: Santana was called up from Triple-A Worcester before the game. RHP Austin Brice was designated for assignment. Brice had a 6.94 ERA in 12 games.
Phillies: C J.T. Realmuto (left wrist bone bruise) was placed on the 10-day injury list, retroactive to May 18. OF Matt Joyce was activated from the injury list.
Red Sox: Verdugo left the game in the sixth because of left hamstring tightness. … INF Christian Arroyo (left wrist contusion) is starting a rehab assignment this weekend.
Phillies: Realmuto could return when he’s eligible in seven days.
RHP Nathan Eovaldi (4-2, 4.50 ERA) takes the mound for the Red Sox and RHP Spencer Howard (0-0, 8.31) will make his first start of the season for the Phillies on Saturday night. Howard will be limited to 60 pitches.
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