Karl-Anthony Towns led Minnesota with 24 points and 14 rebounds. It was his 27th game of the year with 20-plus points and 10-plus rebounds. Rookie Anthony Edwards scored 23 points in the loss.
The Wolves have lost two straight games by double digits heading into Sunday’s season finale.
“I thought we wasted a day,” Towns said.
Minnesota trailed by as many as 23. The Wolves cut the Celtics lead to 11 midway through the fourth quarter on an Edwards three-point play but never got closer.
Boston coach Brad Stevens put Tatum and Fournier back into the game in the fourth when Minnesota trimmed the lead to 11.
“We needed to feel good,” Stevens said. “I thought it was really important when we step on this plane today to feel a little bit better about the win with the right mentality.”
Boston’s Kemba Walker (neck), Tristan Thompson (pectoral), Marcus Smart (calf) and Robert Williams (toe) were all sidelined against Minnesota.
The Celtics connected on 13 of 30 shots from the arc in the first half to build a 66-47 halftime lead. Minnesota was just 2 of 17 from deep in the first two quarters, with its starting lineup going 0 of 14 from 3-point range.