Cole Irvin (9-11) allowed three runs on seven hits in six innings. Yusmeiro Petit and Andrew Chafin pitched a scoreless inning apiece, and Lou Trivino allowed an unearned run in the ninth for his 20th save in 22 opportunities.
Eloy Jiménez put the White Sox ahead with an RBI double in the first. Murphy’s homer tied it in the third, and Tony Kemp drew a bases-loaded walk in the fourth to put the A’s back on top.
Andrew Vaughn put Chicago ahead again with a two-out, two-run homer in the fifth. Chapman tied it with his fifth home run in six games and 19th on the year.
Chicago starter Dylan Cease went six innings, giving up three runs on four hits. He exceeded 100 pitches for the third time in his last four starts.
“It wasn’t great, but I kept us in it,” Cease said. “That helps you swallow one like that a little bit easier. But at the end of the day, losing is not fun, so it’s not much of a consolation prize.”
Zack Collins scored for the White Sox in the ninth when shortstop Elvis Andrus collided with Starling Marte while trying to field a popup to center field. Andrus was charged with the error.
A’s pitcher Chris Bassitt greeted his teammates in the clubhouse before the game, two days after he was struck in the head by a line drive.
Athletics: RHP James Kaprielian (6-4, 3.33 ERA) takes the mound to kick off a three-game home series against the NL-West leading San Francisco Giants on Friday night. LHP Alex Wood (10-3, 4.14) starts for Oakland’s Bay Area rivals.
White Sox: Open a three-game series at AL East-leading Tampa Bay on Friday night, with RHP Lucas Giolito (9-9, 3.83 ERA) pitching against Rays RHP Michael Wacha (2-4, 5.91 ERA).
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