This time, the two attacks both struck early in a vibrant showing by the Swedes at Friends Arena.
Sweden took control of Europe’s Group B with nine points from three games. Spain fell to second place with seven points from four games.
Only the group winners directly qualify for the World Cup. Second-place finishers face a playoff.
“The group is going to be much tougher now,” Spain captain Sergio Busquets said. “We still have lots of games left, even if we don’t have our fate in our hands.”
Soler was the only new face to a Spain lineup which reached the semifinals of the Euros before falling to eventual champion Italy. The Valencia midfielder took the place left by Pedri González, who was given two weeks rest by Barcelona and Spain.
The 24-year-old Soler immediately got involved when he joined in Spain’s first attack. Ferran Torres and Álvaro Morata drew the markings of Sweden’s center backs, allowing Jordi Alba to meet Soler’s run to the right post with a lobbed pass for him to stab home.
Sweden hit right back seconds later when a long ball forward was mishandled by Soler and Sergio Busquets. Isak, who plays for Spanish club Real Sociedad, ran onto the ball and slotted a right-footed shot into the corner of Unai Simón’s net.
Without Pedri to control the ball, Spain had trouble with Sweden’s pressure. Simón got his foot on a low strike by Dejan Kulusevski in the 36th after Koke Resurrección lost possession near the area.
A great move by Kulusevski led to Sweden’s winning goal. The Juventus winger appeared to be hemmed in by two defenders on the left touchline, when he spun past both and found Claesson unmarked in the box.
Spain coach Luis Enrique sent on Adama Traore, Marcos Llorente and Pablo Sarabia to spark his attack. Traore went close to equalizing when he dribbled into the area and forced goalkeeper Robin Olsen to make a save.
But Isak twice broke free on the counterattack and only last-gasp tackles by Eric García and Aymeric Laporte stopped him from having great chances to finish Spain off.
Vedat Muriqi’s first-half goal gave Kosovo a 1-0 win at Georgia.
The first victory for Kosovo left it in third place in Group B with three points from three games. Greece has two points from two games. Georgia has one point from four games.