Ryan Thompson (3-2) got the win after pitching two hitless innings. Jason Adam worked the ninth for his fifth save in six attempts.
Teoscar Hernández drove in Toronto’s runs with a first-inning double and his 15th homer in the fourth. Yusei Kikuchi allowed two runs and three hits in four innings, striking out five.
Rays opener Jalen Beeks pitched one inning and Ryan Yarbrough followed with four innings, giving up Hernández’s homer as his only hit.
Vladimir Guerrero Jr.’s eighth-inning single was Toronto’s only hit in four innings against Thompson, Pete Fairbanks and Adam.
The Blue Jays entered the game as the AL’s wild-card leader after winning 13 of their previous 16 games.
Blue Jays: RHP Ross Stripling was placed on the 15-day IL with a right glut strain. … OF George Springer missed the fourth of five games with a sore right elbow, but he has resumed baseball activities.
Rays: RHP Matt Wisler (neck strain) is almost ready to pitch a rehab inning before being activated. … OF Harold Ramirez, out since July 18, is due for another X-ray on his fractured right thumb.