The 35-year-old Messi has been in great form for league leader PSG this season, netting seven league goals to go with a league-high 10 assists. The record seven-time Ballon d’Or winner also has four goals and four assists in the Champions League.
Messi has netted nine goals in his past three games for Argentina, including a five-goal haul against Estonia at the end of last season. He holds the national record with 90 goals for Argentina, including eight hat tricks.
PSG defender Presnel Kimpembe also has a minor Achilles tendon issue and is being rested for Lorient. He hopes to line up in central defense for defending champion France at the World Cup.
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