The names of the the two people killed were not released. Troopers said they were working to notify family members.
Troopers and the state Department of Fish and Game are planning to travel to Wales once weather allows for it, the dispatch said.
Wales is a small, predominantly Inupiaq town of about 150 people, just over 100 miles (161 kilometers) northwest of Nome.
Fatal polar bear attacks have been rare in Alaska’s recent history. In 1990, a polar bear killed a man farther north of Wales in the village of Point Lay. Biologists later said the animal showed signs of starvation, the Anchorage Daily News reported.
Alaska scientists at the U.S. Geological Survey in 2019 found changes in sea ice habitat had coincided with evidence that polar bears’ use of land was increasing and that the chances of a polar bear encounter had increased.