This week Mark and Margaret speak with Dr. Eric Topol, Director of the Scripps Research Translational Institute. Dr. Topol calls drug maker AstraZeneca’s recent controversial under-reporting of complete safety data to US regulators for its COVID-19 vaccine ‘disturbing’ and ‘unprecedented’ in his clinical trial career. He calls the rapid development of highly successful and effective COVID vaccines one of biomedicine’s greatest achievements and predicts the pandemic crisis will pave the way for more remarkable scientific breakthroughs, and a greater opportunity for the growth of personalized medicine via smartphones.