Head of the Office of Management and Budget Sylvia Mathews Burwell has a tough road ahead if she’s lucky enough to be confirmed as the next Health and Human Services secretary. President Barack Obama tapped her last week to replace Kathleen Sebelius. Burwell will go from the small, inside-the-White-House agency to a sprawling institution that, with Obamacare, is in the eye of the political storm. Elise Viebeck, staff writer at The Hill Newspaper, told Federal Drive hosts Tom Temin and Emily Kopp that Burwell will face five big challenges.

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